Neuroscience and Mental Health
Unbearable Feeling of Anhedonia: Here’s How We Can Enjoy Life Again.
Apathy is a symptom of depression, a cause for self-harm, yet treatable with therapy and a neuroscience-driven approach.
Introduction and Context
Suffering from mood disorders, including unbearable lightness of being due to chronic stress and inflammation in the past, physical and social anhedonia is a topic close to my heart. Thus, I want to create awareness by leveraging scientific development in the field.
We all feel ups and downs in life. It is part of the natural process. However, life becomes meaningless when we experience anhedonia — a lack of pleasure from things that we usually enjoyed in the past.
The closest public term to anhedonia is apathy. This experience depicts a lack of interest, enthusiasm, and concern for enjoyable activities. In addition, apathy is associated with self-harming behavior such as suicide.
When we experience physical anhedonia, we don’t enjoy natural activities concerning our physical sensations.
For example, a touch or a hug from a loved one leaves us empty. Those who were addicted to sex once do not want it anymore when experiencing anhedonia. Some might cry with no stimulus.
There is also social anhedonia associated with reduced social functioning and diminished reward from social interactions. “Individuals expressing social anhedonia are likely to experience reduced social connectedness and feel lonely. Loneliness is associated with reduced social functioning. Thus, loneliness could account for the relationship between social anhedonia and social functioning.”
This study points out that “both physical and social anhedonia is associated with suicidality in major depression. It is a cross-sectional study investigating the association of physical and social anhedonia with suicidality in patients with major depressive disorder.”
What can we do?
The sensible approach is being aware of the symptoms and communicating them to a qualified healthcare professional who can diagnose the conditions and provide valuable tools to address the underlying issues and mitigate risks.
Partnership with qualified practitioners is critical. Awareness of our situations is important because if we don’t know and communicate our symptoms, professionals won’t know about them. No professional is a mind-reader.
In this post, I introduce common symptoms of anhedonia, root causes, and coping mechanisms based on my scientific literature review.
An Overview of Anhedonia
Are you constantly feeling down, and the things you used to enjoy immensely do not give you any pleasure anymore?
Are you declining invitations to festive parties where once you enthusiastically participated and had lots of fun and joy?
If you don’t enjoy your previous hobbies or social gatherings that gave you pleasure once, you might be experiencing anhedonia. Awareness of this common condition is critical for our mental health and well-being.
One in one hundred people have major depression symptoms. Some are severely affected and end up self-harming.
Anhedonia is felt in both polar and non-polar depression. In polar depression, people feel excessive joy for a while, then they fully crash and feel depressed for some time.
In non-polar depression, also known as major depression, symptoms show a flat state of non-enjoyment from things that we used to have lots of pleasure in before. Thus, anhedonia is one of the symptoms of major depression.
Anhedonia is a complex phenomenon linked to several pathways in our neurobiology. It has biological, neural, and psychological connections.
Vegetative symptoms depict the existence of anhedonia. These symptoms might reflect not feeling good about doing something, especially for things we used to get much pleasure from.
Anhedonia is closely associated with hormones and neurotransmitters. For example, the ghrelin hormone, which makes us hungry, does not function anymore. Thus, a person experiencing anhedonia might not enjoy their favorite food. More precisely, it does not give any meaning to their life.
Another example is the deficiency of sex hormones such as testosterone, estrogen, and oxytocin. People experiencing a lack of these hormones might not enjoy intimacy and lovemaking as they do not give them pleasure.
According to this paper, “anhedonia is characteristic of depression, some types of anxiety, and substance abuse and schizophrenia. Anhedonia is a predictor of poor long-term outcomes, including suicide and poor treatment response. Because extant psychological and pharmacological treatments are relatively ineffective for anhedonia, there is an unmet therapeutic need for this high-risk symptom.”
The paper points out that “current psychological and drug treatments for anxiety and depression focus largely on reducing excesses in negative affect rather than improving deficits in positive affect. Recent advances in affective neuroscience posit that anhedonia is associated with deficits in the appetitive reward system, specifically the anticipation, consumption, and learning of reward. The study describes the therapeutic approach for Positive Affect Treatment (PAT), an intervention designed specifically to target deficits in reward sensitivity.”
Causes of Anhedonia
Even though anhedonia is mainly associated with major depression, other conditions such as dysthymia, schizophrenia, diabetes, Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, bipolar disorders, progressive supranuclear palsy, stroke, and even coronary artery disease can trigger this condition.
These health conditions cause changes in neural activities in the brain. Based on preliminary research in neuroscience and psychiatry, especially in animal studies, it depicts the mechanism associated with dopamine. It is our feel-good neurotransmitter for seeking rewards.
Other neurotransmitters and hormones, such as lack of serotonin and elevated stress hormone (cortisol), is also associated with anhedonia. For example, when we have serotonin deficiency, we can experience grief, guilt, and exhaustion symptoms.
Some recent animal studies provide glimpses on causes. For example, this paper indicates that “during 30-day experimental neurosis and eight-week depression-like behavior cause the development of anhedonia. Therapeutic use of amide 2-hydroxy-N-naftalen-1-il-2-(2-oxo-1,2-dihidro-indole-3-iliden) and ethyl ether 4-[2-hydroxy-2-(2-oxo-1,2-dihidro-indole-3-iliden)-acetamin]-butyric acid effectively corrected anhedonia after experimental neurosis and chronic mild stress in rats.”
Anhedonia Treatment
Anhedonia specialists mainly use SSRIs (Selective Serotonin Reuptake Inhibitors), therapeutic molecules, and talk therapy to apathy symptoms. SSRIs are prescribed as antidepressants and are also used for the treatment of anxiety disorders.
Talk therapy has several benefits, such as reducing stress, identifying early signs of conditions, and giving a broader perspective on a problem. Talk therapy can include individual, family, and group therapies. Talk therapy is usually supplemented with appropriate medications.
Interestingly, some recent studies indicate that ketamine might work for relief from anhedonia. This paper mentions that “ketamine, administered in subanesthetic doses, is an effective off-label treatment for severe and even treatment-refractory depression; however, despite dozens of studies across nearly two decades of research, there is no definitive guidance on matters related to core practice issues.”
While psychiatrists and neurologists work on treatments, the research is active in the area. Many studies have been conducted. Some studies refer to transdiagnostic approaches. This paper indicates that “a transdiagnostic approach that cuts across traditional disease boundaries provides a potentially useful means for understanding apathy and anhedonia conditions.”
Impact of Chronic Stress on Depressive Conditions
Excessive inflammation caused by chronic stress is associated with major depression. Depression relates to excessive inflammation. When we are chronically stressed, the brain gets inflamed. The cells in the brain get disrupted. This is a complex and comprehensive topic, but I want to give a simple example of leveraging scientific papers.
Without going into detail, I want to point out that even though we consume enough nutrition, inflammation affects the utilization of nutrition. For example, tryptophan, the precursor to serotonin, unfortunately, converts to neurotoxins when too much inflammation occurs in the brain. So even though we nutritionally feed ourselves, the inflammation disrupts the conversion process and uses the neuro-toxic pathway.
As pointed out in this paper, “chronic stress and infections can shunt available tryptophan toward the kynurenic pathway and thereby lower 5-HT (serotonin receptors) synthesis.”
In accordance with this, dietary fatty acids affecting the pro-inflammatory cytokines have been suggested to affect the metabolic fate of tryptophan. In addition, exercise is known to help with the conversion of tryptophan to serotonin naturally and effectively. Serotonin is an essential neurotransmitter for a good mood.
Essential fatty acids can reduce inflammation. One of the known tools to minimize inflammation is EPA (Eicosapentaenoic acid). Nutritionists recommend at least a gram of EPA for managing inflammation. It is also used for cardiovascular health. We can get EPA from fish or supplements such as fish oil and krill oil. However, reading the label for EPA in supplements matters as the amount of fish oil might not cover a sufficient amount of EPA.
Another promising supplement for depressive symptoms mentioned in the literature is creatine. For example, this paper notes “growing evidence from human neuroimaging, genetics, epidemiology, and animal studies that disruptions in brain energy production, storage, and utilization are implicated in the development and maintenance of depression. Creatine, a widely available nutritional supplement, has the potential to improve these disruptions in some patients, and early clinical trials indicate that it may have efficacy as an antidepressant agent.”
Compelling Thoughts & Ideas on Anhedonia
There are many ideas offered by thought leaders.
Addictive behavior is commonly discussed in health communities. For example, addiction to porn leads to disinterest in sex at a later stage and causes hormonal and neurotransmitter imbalance. For example, excessive pleasures exceed the dopamine threshold; hence, the body regulates the pain and pleasure pathways.
Other topics in the health forums relate to addictive behaviors such as recreational drugs, alcohol, nicotine, caffeine, online gaming, social media, excessive sex, and other hedonistic activities.
Excessive hedonistic behaviors are believed to cause emotional detachment and numbness after overconsumption. This type of behavior is mainly observed in teenagers obsessed with hedonistic activities disrupting the natural flow of neurochemicals and hormones.
Conclusions
Some of us experience mild and major depression due to various reasons. However, living with apathy can be unbearable.
We need to control our physical and emotional stress by preventing them from reaching a chronic state as a preventative measure.
Smart lifestyle changes can help us avoid a depressive state. Lifestyle considerations such as quality nutrition, moderate exercise, adequate sleep, sunlight exposure, relaxation, and meditation are a few commonly recommended preventative measures.
Physical interventions such as exercise and cold showers can release neurotransmitters to relieve depression symptoms. For example, we know that exercise is protective by stimulating the release of dopamine, norepinephrine, and serotonin.
The problem is depressed people don’t feel like taking exercise or cold showers as they cannot access the circuits like normal people. Thus, they may need medication to fix problems in those circuits. So, prescribed medication might be required to increase the interest of patients in participating in these activities.
My point is despite our efforts to use preventative measures, if we experience symptoms of anhedonia, we need to accept it and seek professional advice with confidence. We might self-diagnose our conditions; however, working with a professional who can methodically diagnose them is always essential.
Observing and identifying symptoms is essential, but getting advice for proper diagnostics is critical too. We need to partner with our healthcare professionals.
I see the opposite of anhedonia as euphoria. Here’s how I initiate euphoric feelings deliberately as needed.
Thank you for reading my perspectives. I wish you a healthy and happy life. I hope the following two pieces can provide valuable perspectives on cognitive and emotional balance.
Here’s How I Eliminated Depressive/Suicidal Feelings in 7 Steps in My Younger Years
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