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Summary

The article provides an update on the author's personal experimentation with peptides, detailing dosages, effects, and anecdotal evidence from peers, while also discussing future areas of exploration in peptide research.

Abstract

The author shares insights from continued experimentation with peptides following an initial publication of their effects. Dosages of BPC-157, Epitalon, Thymalin, and GHK-CU were adjusted to isolate specific effects, with findings indicating a relationship between BPC-157 dosage and sex drive, and the efficacy of Epitalon and Thymalin in improving skin quality. The author also reports on the experiences of three acquaintances who incorporated TB-500 into their regimen, with varying degrees of success in addressing conditions such as post-surgery back pain, chronic Lyme disease, and accident-related back and joint issues. The article concludes with the author's intention to investigate other peptides like LL-37, TA-1, and FOX-O-DR4 for their potential health benefits, despite the complexity and potential side effects. Additionally, the author is currently experimenting with nootropic peptides Semax and Selank, with positive initial results.

Opinions

  • The author believes in the efficacy of peptides for various health benefits, including healing, skin quality, and mood stabilization.
  • There is a clear dosage-dependent effect of BPC-157 on sex drive, as observed by the author.
  • The author values the importance of isolating peptides to understand their individual effects, as demonstrated by the pause and restart approach in their experimentation.
  • The author suggests that the combination of Epitalon and Thymalin, and later Epitalon alone, has a significant positive impact on skin health.
  • The GHK-CU serum is considered effective by the author, both as a standalone treatment and in conjunction with injectable Epitalon.
  • The author has discontinued the use of injectable GHK-CU due to the associated pain and discomfort.
  • The anecdotal evidence from friends suggests that peptides, particularly when combined with TB-500, may offer relief from chronic pain and improve mood, although results vary depending on the individual and condition.
  • The author expresses excitement about the potential of new peptides like LL-37, TA-1, and FOX-O-DR4 but also acknowledges the challenges and risks due to their complex systemic interactions.
  • The author is enthusiastic about the ongoing experimentation with Semax and Selank, indicating promising results in cognitive enhancement without stimulant-like side effects.

Peptides round two — Update and Findings

Photo by Matt Briney on Unsplash

A couple of months have passed since the first round of peptide experiments concluded. Well, not concluded but rather published here to share the initial results. The experimentation went on afterward and there are interesting updates to share:

As a recap my first round dosage from the first article was: 1000mcg BPC-157 in two injections (morning, evening) 5mg Epitalon (once daily) 5mg Thymalin (once daily) HGK-CU topical serum as needed

In the meantime, I have gotten a lot of questions and I want to update my findings. One of the questions was: “How could I know which effects came from which peptide since you mixed them all as a stack?”

The first indication is the studies that describe the range of possible effects. If the research and experience reports from multiple sources describe certain effects than that is an indication of effects.

Secondly, after I wrote the article, I paused the peptide regimen for about 3 weeks completely. I then restarted single peptides at various dosages to really single out effects.

The results

BPC-157 @ 500mcg (once daily). This is a reduced dosage from previously 2x 500mcg. The healing effects seemed to remain, even though not quite as strong. I was still eager to work out and recovery worked quite well. My sex drive balanced out to a more “normal” level. The teenager horniness was gone. Which was not too bad, since a super high sex drive can bring all kinds of issues and strains with it.

When dosing back up to 1000mcg the sex drive reverted back to superpower mode. Dialing it back down to 500mcg eased the sexual pressure again. So, in this case, there is a clear relationship between dosage and sex drive while using the BPC-157. And to be clear I used BPC-157 for which you will not find many other reports of increased sex drive online. I did not use at any point Melatonan or HGH which is known for its sex drive increasing behavior.

As a side note, it is quite interesting to observe how sexual urges inherently shape thinking and behavior while experiencing a heightened sex drive. With hormones raging it was difficult not to mess my very happy existing relationship up — as every walk in town or the metro was a porn fest of desire in my head. It felt like having to tame a cart raced by 10 wild horses. From that experience, it is easy to see why the suppression of sexuality is/was used throughout history as a means of power and control.

Epitalon @ 5mg (daily) The BPC-157 alone did not seem to have much effect on my skin. It started to become dry again. Mainly because of the bad water quality where I live, but the peptides of the previous protocol counteracted that effect very well. Since I didn’t like to have dry skin I tried the Epitalon and Thymalin again at 5mg each once a day.

Within 3 days my skin started to become smoother and less dry again. So this narrowed down the action on the skin to two substances. Later when I ran out of Thymalin I continued with the Epitalon alone and the effects on the skin remained stable for weeks. Dropping off the Epitalon lets the skin get drier within a week. In another environment with better water quality (non-chlorinated), the skin remains stable.

GHK-CU Serum The topical GHK-CU serum which I also used in the first protocol helps with my skin noticeably. I’m still using it even when I don't use other peptides. However, the effects on my skin are stronger (better) and cover the entire body when I inject the Epitalon. The skin gets smooth, I hardly need any lotion and there is more tension in the skin. I use the GHK-CU only as an additional anti-wrinkle and cream substitute on my face now once in a while.

GHK-CU (injectable) The injectable form of GHK-CU has many positive effects reported in various studies and I would love to take it on a full regimen every day. However, I tried multiple times with varying doses in varying spots of my body. The result: No matter the dosage and no matter where I injected, it hurt pretty bad. The burning sensation remained quite strong for several days and the peptide stayed in place for several days as a lump under the skin. I have not found a workaround and it’s the only peptide I stopped using.

Anecdotal experiences

As it comes with any interest one makes acquaintances and friends with people who have similar interests. Three of these people I know quite well and we have an ongoing exchange. Therefore I include their findings here as well for completeness and to broaden the perspective.

One friend had back surgery on a herniated disc. The surgery went well but he still had quite severe pain in his back several months after the surgery. He could not work out and even had difficulties getting out of bed some mornings. He started the full regimen with the addition of TB-500 at 5mg twice a week. Within one week he reported the pain to be gone and he could slowly go back to the gym. He was amazed at how fast his pain went away.

Another friend took the same full regimen with the addition of the TB-500 at 5mg twice a week as well. He had severe symptoms from chronic Lyme disease. He reported a mood-stabilizing effect and more energy which was an improvement for him. However, the peptides did not cure or significantly impact the Lyme symptoms. He was on the regimen for 3 months.

The last person also started with the full regimen as he had to deal with back and joint problems caused by an accident many years back. Additionally, he dealt with mood problems. He reported pain relief as well within the first two weeks and a noticeable improvement in his mood.

What’s next?

If you read until here you know I’m excited about peptides. There are many more peptides for very specific conditions and new research is being released all the time.

At the moment, I am looking deeper into LL-37 which is an Anti-microbial and Anti-fungal peptide. Another interesting one is TA-1 which some people use in their Lyme and cancer treatment. Their effects look promising, but both peptides are much more complex in their functioning than the ones described in my first article and above. The drawback of that complexity is possible negative side effects. They work systemically and have various interactions that are hard to judge and anticipate for non-medically trained people (like me) and without intensive body screening.

Another interesting peptide is FOX-O-DR4. It seems to be one of the strongest anti-aging peptides around with few or no side effects. It reportedly has the power to return the color to greyed hair. Unfortunately, there is not a large market for it yet which makes prices prohibitively expensive for most. A serious regimen for a couple of months would likely cost somewhere between 10.000–20.000 USD.

Currently, I am experimenting quite successfully with Semax and Selank. Both are nootropic peptides administered as a nasal spray. They are used in Alzheimer, memory loss and mood stabilization cases. My experience is they work wonders for focus, mood, memory and being “on-it” without any “speedy” effects. More to come on that in the future.

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Find here the Nootropic Peptide Regimen and its results

https://readmedium.com/peptides-perfected-my-daily-nootropic-protocol-after-years-of-experimentation-e73009e70864

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