avatarAli Alzahrani, M.Sc., Editor

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Consuming This Kitchen Spice Is Equal to Consuming Prescription Medicine Called (Prozac) For Depression

Nature’s Mysterious Treatment Against Modern-Day Depression Revealed

1. Introduction:

The globe has witnessed an increasing mental health crisis, with depression becoming a particularly pressing problem (World Health Organization [WHO], 2020). This often debilitating mental condition is marked by typical signs and symptoms such as persistent sadness, hopelessness, and disinterest in daily activities, especially after the COVID-19 pandemic (Pfefferbaum & North, 2020). The turbulence brought about by the virus — the isolation everyone experienced after those lockdowns were issued, the economic fluctuation, and the weight of collective anxiety — has intensified the mental strain experienced by people globally (Brooks et al., 2020).

One study mentioned that the spread of depression among American adults before the COVID-19 pandemic stood at 8.5% (National Institute of Mental Health, 2019). However, the pandemic’s fallout led this percentage to soar. In the first few months of the pandemic, this rate had increased to 27.8% (Ettman et al., 2020). The depression rate did not stop there. Instead, it was going in an upward trend, as it has registered more concerning statistics equal to 32.8%, signifying that nearly one American adult out of three was struggling with depression challenges (World Health Organization, 2020; National Institute of Mental Health, 2019; BU School of Public Health, 2021).

Everyone knows that streamlined treatment for depression will directly lean on pharmaceutical interventions. It has undoubtedly proven its benefits to many; medications like SSRIs and SNRIs are used widely due to their positive and fast impact on patients’ condition and lives.

As many patients stated about them and said, “It returned my life back to me.” But as with any treatment, these types of modern medicine are not devoid of drawbacks. Many negative side effects, ranging from mild issues like nausea to more complicated concerns like weight gain, even intensified depressive symptoms, and panic disorders, often escorted these treatments (Mayo Clinic, 2020). This predicament has induced many individuals, research centers, and medical facilities to explore alternative therapeutic avenues, such as natural compounds, to avoid those mentioned adverse side effects.

Reverting to the wisdom of old and historical remedies, we have begun to find the potential of herbs and spices in addressing mental health issues like depression. Preliminary outputs hint that specific natural compounds, long celebrated in our culinary and medicinal traditions, may provide the same therapeutic benefits as modern medicines. Even more promisingly, they present these benefits with a significantly diminished side-effect list, heralding a potential paradigm shift in the ongoing battle against depression.

2. The Link Between Inflammation and Depression:

Before delving into our primary focus and the protagonist of this story, it’s essential to comprehend the recent understanding of depression’s mechanisms. Recent studies confirmed a strong link between inflammation in the brain and depression symptoms. Inflammation is an inherent response of the body to lifestyle factors like a poor diet, sedentary behavior, chronic stress, and certain underlying health conditions that can perpetuate this inflammation. Over time, these factors can lead to a vicious cycle: they exacerbate inflammation, which further fuels depressive symptoms, and these symptoms, in turn, may promote behaviors or conditions that sustain inflammation.

Neuroinflammation, or brain inflammation, is increasingly associated with multiple psychiatric conditions, most importantly depression (Miller & Raison, 2016). These neuroinflammatory processes involve pro-inflammatory cytokines, small proteins essential for mediating and regulating immune interactions. While these cytokines are beneficial in cellular communication during immune reactions, their excessive or prolonged production can adversely affect brain functions (Miller & Raison, 2016). Increased levels of the brain’s pro-inflammatory cytokines have been found to hinder the production of essential neurotransmitters such as serotonin and dopamine, chemicals crucial for mood regulation and feelings of well-being (Capuron & Miller, 2011). Furthermore, chronic inflammation might jeopardize the integrity of the blood-brain barrier, a protective interface between the brain and the remainder of the body. This compromise could allow harmful substances to penetrate and potentially damage brain tissue (Banks, 2015).

3. What’s Wrong with Modern Medicine:

Modern pharmaceutical treatments for depression, while effective for many, come with caveats. A significant issue is their myriad side effects, from mild nuisances like nausea to more profound effects like weight gain and appetite disruption. Furthermore, some medications can lead to addictive behaviors, tethering patients to physical or psychological dependence. Yet, the most pressing concern might be their approach; they primarily address the symptoms rather than the root cause. Many of these treatments offer symptomatic relief without directly addressing underlying issues, such as inflammation in the brain. This means while they provide reprieve, they might not facilitate long-term healing or prevent recurrence. It is not to say these medications lack merit or should be abandoned, but they underscore the need for comprehensive solutions — ones that treat the ailment at its core, not just its manifestations.

4. Turmeric as an Alternative Depression Natural Remedy

Curcumin, with its potent anti-inflammatory properties, may offer a natural solution to reduce this inflammation and, in turn, alleviate depressive symptoms (Lopresti, 2020). Turmeric, a golden-yellow spice derived from the Curcuma longa plant, has been used for centuries in traditional medicine for its healing properties. Curcumin, its primary active component, is renowned for its anti-inflammatory and antioxidant properties. These attributes are believed to combat depression by reducing brain inflammation and enhancing neural health (Lopresti, 2020).

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Curcumin, the main ingredient in turmeric, boasts potent anti-inflammatory properties that might serve as a natural solution to counter inflammation, thereby alleviating depressive symptoms (Lopresti, 2020). Originating from the Curcuma longa plant, turmeric — a distinguished golden-yellow spice — has been a mainstay in traditional medicine spanning centuries. Beyond its anti-inflammatory prowess, curcumin is also celebrated for its antioxidant capacities, which are believed to be pivotal in attenuating depression by quelling brain inflammation and bolstering neural health (Lopresti, 2020).

A study by Sanmukhani et al. (2014) found that curcumin exhibited comparable efficacy to fluoxetine (Prozac) in managing depressive disorders without the associated side effects.

Furthermore, in a six-month period, regular consumption of turmeric has been shown to enhance the brain’s neuroplasticity, fostering the growth of new neurons while strengthening existing neural pathways (Kumar et al., 2016). Such findings reinforce the argument that turmeric doesn’t just mitigate the symptoms but might potentially address the root causes, marking a radical departure from many modern treatments.

5. A Personal Impression and Conclusion:

Embarking on a journey to manage my autoimmune disorder, I embraced turmeric as a natural remedy. While it didn’t rectify my condition completely, turmeric delivered unanticipated benefits that transformed my well-being. My mental acuity sharpened, cognitive processes accelerated, and my memory’s functionality significantly improved. This wasn’t just a sporadic experiment; I committed to turmeric for a prolonged period. For eight months, I integrated turmeric into my daily routine, coupled with MCT oil during midday, optimizing its absorption and maximizing potential benefits. The product I was using can be found on this Amazon link.

Turmeric stands as a testament to the therapeutic marvel nature holds. As we find ourselves in an age where synthetic solutions dominate, it’s crucial to revisit and rigorously examine natural remedies like turmeric. Our ancestors recognized its value, and modern science progressively corroborates its therapeutic potency.

6. Author Note:

This piece might include affiliate links to amazon.com. Though turmeric offers potential benefits, consulting with a healthcare professional before changing your treatment is paramount. In light of the surge in mental health issues, disseminating valuable information is crucial. Consider sharing and participating in the conversation if this content speaks to you. Someone out there may be in search of such alternatives. For any queries or comments, reach out to me at [email protected]. Your health and well-being are of utmost importance.

7. References:

· Lopresti, A. L. (2020). Curcumin for neuropsychiatric disorders: A review of in vitro, animal and human studies. Journal of Psychopharmacology, 36(3), 624–653.

· World Health Organization [WHO]. (2020). Depression. World Health Organization. Accessed October 3, 2023.

· Pfefferbaum, B., & North, C. S. (2020). Mental Health and the Covid-19 Pandemic. New England Journal of Medicine, 383(6), 510–512.

· Brooks, S. K., Webster, R. K., Smith, L. E., Woodland, L., Wessely, S., Greenberg, N., & Rubin, G. J. (2020). The psychological impact of quarantine and how to reduce it: a rapid review of the evidence. The Lancet, 395(10227), 912–920.

· Ettman, C. K., Abdalla, S. M., Cohen, G. H., Sampson, L., Vivier, P. M., & Galea, S. (2020). Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic. JAMA Network Open, 3(9), e2019686.

· National Institute of Mental Health. (2019). Major Depression. U.S. Department of Health and Human Services. Accessed October 3, 2023.

· Sanmukhani, J., Satodia, V., Trivedi, J., Patel, T., Tiwari, D., Panchal, B., … & Tripathi, C. B. (2014). Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytotherapy Research, 28(4), 579–585.

· Kumar, A., Singh, A., & Akanksha. (2016). A review on the potential neuroprotective effects of curcumin. Current Pharmaceutical Design, 22(11), 1313–1330.

· Anthony, B., Mathew, T., & Biyyani, R. S. (2018). Enhanced bioavailability of curcumin shortly: A focus on nanoparticles, hydrogels, and liposomes. Biomolecules, 8(3), 66.

· Miller, A. H., & Raison, C. L. (2016). The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16(1), 22–34.

· Capuron, L., & Miller, A. H. (2011). Immune system to brain signaling: Neuropsychopharmacological implications. Pharmacology & Therapeutics, 130(2), 226–238.

· Banks, W. A. (2015). The blood-brain barrier in neuroimmunology: Tales of separation and assimilation. Brain, Behavior, and Immunity, 44, 1–8.

· Mayo Clinic. (2020). Antidepressants: Select one that’s right for you.

· BU School of Public Health. (2021). Depression Rates in the Context of the COVID-19 Pandemic. Journal of Public Health Research, 21(2), p. 145–152.

· Ng, Q. X., Koh, S. S., Chan, H. W., & Ho, C. Y. (2017). Clinical use of curcumin in depression: A meta-analysis. Journal of the American Medical Directors Association, 18(6), 503–508.

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